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Clinical Considerations Before Starting GLP-1 Therapy Shared decision-making is essential

Hair thinning or hair loss (alopecia) has been reported in clinical trials of tirzepatide, particularly in the weight management studies

Atherosclerosis-model mice treated with exendin-4, another GLP-1RA, also demonstrated reduced circulating levels of monocyte chemoattractant protein-1, C-X-C motif chemokine ligand-1 (CXCL-1), and ultimately neutrophil recruitment (Wang et al., 2014)